|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>iNOS</i> rs2297518 and <i>eNOS</i> rs2070744 polymorphisms may represent susceptible factors for gastric cancer.
|
29765229 |
2018 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNP Ser608Leu was not associated with risk of chronic gastritis or gastric cancer.
|
20565800 |
2010 |
|
Septicemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the NOS2 rs2297518 may play a role in mediating the susceptibility to septic shock in patients with sepsis in Chinese populations.
|
23192595 |
2013 |
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the NOS2 rs2297518 may play a role in mediating the susceptibility to septic shock in patients with sepsis in Chinese populations.
|
23192595 |
2013 |
|
Recurrent aphthous ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Inheritence of a NOS2 single-nucleotide polymorphism rs2297518 is associated with increased risk of recurrent aphthous stomatitis in a Jordanian population.
|
21481004 |
2011 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>A] and NOS3 [endothelial NOS; IVS1-762C>T, Ex7-43C>T (D258D), IVS7-26A>G, Ex8-63G>T (E298D) and IVS15-62G>T].
|
19168583 |
2009 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association of NOS2 polymorphisms Ser608Leu (rs2297518) in exon 16, -954G/C and -1173C/T, both in the promoter region, with gastric cancer and chronic gastritis and the association of cancer with risk factors such as smoking, alcohol intake and H. pylori infection.
|
20565800 |
2010 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results indicated that the polymorphisms in iNOS gene (C150T(Ser(608) Leu) polymorphism and polymorphic (CCTTT)n repeats) had no association with cancer risk for all genetic models.
|
26391304 |
2015 |
|
Pregnancy associated hypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined whether two functional, clinically relevant iNOS genetic polymorphisms (the C(-1026)A polymorphism, rs2779249, in the promoter region, and the G2087A polymorphism, rs2297518, in exon 16) are associated with GH or with PE.
|
21716319 |
2012 |
|
Peptic Esophagitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no significant association between this polymorphism and risk of Barrett's esophagus or reflux esophagitis or between the iNOS Ser 608 Leu polymorphism and risk of these esophageal conditions.
|
18349295 |
2008 |
|
MILES-CARPENTER X-LINKED MENTAL RETARDATION SYNDROME
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the reported association of nitric oxide synthase (NOS) gene polymorphisms with inflammatory disorders, we aimed to investigate the distribution of NOS2A -2.5 kb (CCTTT) n as well as Ser608Leu and NOS3 -786T>C variants and their correlation with nitrite/nitrate levels, in a study cohort including 170 MCS, 108 suspected MCS (SMCS), 89 FM/CFS, and 196 healthy subjects.
|
25878398 |
2015 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that two functional, clinically relevant iNOS genetic polymorphisms (C(-1026)A-rs2779249 and G2087A-rs2297518) are associated with migraine with or without aura.
|
22234503 |
2012 |
|
Mast-Cell Sarcoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the reported association of nitric oxide synthase (NOS) gene polymorphisms with inflammatory disorders, we aimed to investigate the distribution of NOS2A -2.5 kb (CCTTT) n as well as Ser608Leu and NOS3 -786T>C variants and their correlation with nitrite/nitrate levels, in a study cohort including 170 MCS, 108 suspected MCS (SMCS), 89 FM/CFS, and 196 healthy subjects.
|
25878398 |
2015 |
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Only NOS2A rs2297518 was associated with colon cancer (OR 0.86 95% CI 0.74, 0.99) and EPX rs2302313 and MPO rs2243828 were associated with rectal cancer (OR 0.75 95% CI 0.59, 0.96; OR 0.81 95% CI 0.67, 0.99 respectively) for main effects.
|
22531693 |
2012 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results indicated that the polymorphisms in iNOS gene (C150T(Ser(608) Leu) polymorphism and polymorphic (CCTTT)n repeats) had no association with cancer risk for all genetic models.
|
26391304 |
2015 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association of NOS2 polymorphisms Ser608Leu (rs2297518) in exon 16, -954G/C and -1173C/T, both in the promoter region, with gastric cancer and chronic gastritis and the association of cancer with risk factors such as smoking, alcohol intake and H. pylori infection.
|
20565800 |
2010 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNP Ser608Leu was not associated with risk of chronic gastritis or gastric cancer.
|
20565800 |
2010 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
<i>iNOS</i> rs2297518 and <i>eNOS</i> rs2070744 polymorphisms may represent susceptible factors for gastric cancer.
|
29765229 |
2018 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>A] and NOS3 [endothelial NOS; IVS1-762C>T, Ex7-43C>T (D258D), IVS7-26A>G, Ex8-63G>T (E298D) and IVS15-62G>T].
|
19168583 |
2009 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Specifically, for nitric oxide synthase (NOS2A Ser608Leu, rs2297518) Leu/Leu homozygotes, there was a 2-fold risk increase for NHL (OR=2.2, 95% CI=1.1-4.4) (referent=Ser/Ser and Ser/Leu).
|
16543247 |
2006 |
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
Specifically, for nitric oxide synthase (NOS2A Ser608Leu, rs2297518) Leu/Leu homozygotes, there was a 2-fold risk increase for NHL (OR=2.2, 95% CI=1.1-4.4) (referent=Ser/Ser and Ser/Leu).
|
16543247 |
2006 |
|
Liver Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
One hundred and thirty-two patients with liver cirrhosis (age 36-72 years) and 101 controls were examined for functional variants of eNOS (E298D, 27bpintr4, 786T/C) and iNOS (R221W, S608L) genes.
|
23452051 |
2013 |
|
Infection caused by Helicobacter pylori
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association of NOS2 polymorphisms Ser608Leu (rs2297518) in exon 16, -954G/C and -1173C/T, both in the promoter region, with gastric cancer and chronic gastritis and the association of cancer with risk factors such as smoking, alcohol intake and H. pylori infection.
|
20565800 |
2010 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant associations between rs2297518 (G/A) variants alone and hypertension were found.
|
26579803 |
2015 |
|
Gastro-esophageal reflux disease with esophagitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no significant association between this polymorphism and risk of Barrett's esophagus or reflux esophagitis or between the iNOS Ser 608 Leu polymorphism and risk of these esophageal conditions.
|
18349295 |
2008 |